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Article

Patients with systemic sclerosis present increased DNA damage differentially associated with DNA repair gene polymorphisms.

The Journal of rheumatology - 1 Mar 2014

Palomino Gustavo Martelli, Bassi Carmen L, Wastowski Isabela J, Xavier Danilo J, Lucisano-Valim Yara M, Crispim Janaina C O, Rassi Diane M, Marques-Neto Joao F, Sakamoto-Hojo Elza T, Moreau Philippe, Sampaio-Barros Percival D, Donadi Eduardo A

Abstract excerpt

OBJECTIVE: Patients with systemic sclerosis (SSc) exhibit increased toxicity when exposed to genotoxic agents. In our study, we evaluated DNA damage and polymorphic sites in 2 DNA repair genes (XRCC1 Arg399Gln and XRCC4 Ile401Thr) in patients with SSc. METHODS: A total of 177 patients were studied for DNA repair gene polymorphisms. Fifty-six of them were also evaluated for DNA damage in peripheral blood cells...

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Share to DNA-Binding Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Gene Frequency

Share to Genomic Instability

Share to Polymorphism, Genetic

Share to Scleroderma, Systemic

Share to X-ray Repair Cross Complementing Protein 1

Source

Identifiers

PMID: 24488411
DOI: 10.3899/jrheum.130376

Genes

XRCC1
XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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