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Article

Type 1 interferon activation in systemic sclerosis: a biomarker, a target or the culprit

16 Sept 2022

Abstract excerpt

PURPOSE OF REVIEW: Activation of the type 1 interferon (T1 IFN) pathway has been implicated in the pathogenesis of systemic sclerosis (SSc) by an increasing number of studies, most of which share key findings with similar studies in systemic lupus erythematosus (SLE). Here we will focus on the evidence for T1 IFN activation and dysregulation in SSc, and the rationale behind targeting the pathway going forward....

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PMID: 36125916
DOI: 10.1097/bor.0000000000000907

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