Article
Oxidative stress-induced senescence mediates inflammatory and fibrotic phenotypes in fibroblasts from systemic sclerosis patients.
Rheumatology (Oxford, England) - 2 Mar 2022
Kizilay Mancini Ozge, Acevedo Mariana, Fazez Nesrine, Cuillerier Alexanne, Fernandez Ruiz Ana, Huynh David N, Burelle Yan, Ferbeyre Gerardo, Baron Murray, Servant Marc J
Abstract excerpt
OBJECTIVE: SSc is an autoimmune connective tissue disorder characterized by inflammation and fibrosis. Although constitutive activation of fibroblasts is proposed to be responsible for the fibrotic and inflammatory features of the disease, the underlying mechanism remains elusive, and effective therapeutic targets are still lacking. The aim of this study was to evaluate the role of oxidative stress-induced...
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