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Article

Egr-1 Induces a Profibrotic Injury/Repair Gene Program Associated with Systemic Sclerosis

13 Sept 2011

Abstract excerpt

Transforming growth factor-ß (TGF-ß) signaling is implicated in the pathogenesis of fibrosis in scleroderma or systemic sclerosis (SSc), but the precise mechanisms are poorly understood. The immediate-early gene Egr-1 is an inducible transcription factor with key roles in mediating fibrotic TGF-ß responses. To elucidate Egr-1 function in SSc-associated fibrosis, we examined change in gene expression induced by...

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PMID: 21931594
DOI: 10.1371/journal.pone.0023082

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