GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia.

doi:10.1038/s41588-024-01939-9

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Article

GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia.

Nature genetics - 1 Nov 2024

Shade Lincoln M P, Katsumata Yuriko, Abner Erin L, Aung Khine Zin, Claas Steven A, Qiao Qi, Heberle Bernardo Aguzzoli, Brandon J Anthony, Page Madeline L, Hohman Timothy J, Mukherjee Shubhabrata, Mayeux Richard P, Farrer Lindsay A, Schellenberg Gerard D, Haines Jonathan L, Kukull Walter A, Nho Kwangsik, Saykin Andrew J, Bennett David A, Schneider Julie A, Ebbert Mark T W, Nelson Peter T, Fardo David W

Abstract excerpt

Genome-wide association studies (GWAS) have identified >80 Alzheimer's disease and related dementias (ADRD)-associated genetic loci. However, the clinical outcomes used in most previous studies belie the complex nature of underlying neuropathologies. Here we performed GWAS on 11 ADRD-related neuropathology endophenotypes with participants drawn from the following three sources: the National Alzheimer's...

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PMID: 39379761
DOI: 10.1038/s41588-024-01939-9
PMCID: PMC11549054

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