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Integrative multi‐omics analysis reveals the critical role of the PBXIP1 gene in Alzheimer's disease

20 Nov 2023

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder, and its strongest risk factor is aging. A few studies have explored the relationship between aging and AD, while the underlying mechanism remains unclear. We assembled data across multi-omics (i.e., epigenetics, transcriptomics, and proteomics, based on frozen tissues from the dorsolateral prefrontal cortex) and neuropathological and clinical traits from...

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PMID: 37984333
DOI: 10.1111/acel.14044

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