Article
Origins and Molecular Evolution of the NusG Paralog RfaH.
mBio - 27 Oct 2020
Wang Bing, Gumerov Vadim M, Andrianova Ekaterina P, Zhulin Igor B, Artsimovitch Irina
Abstract excerpt
The only universally conserved family of transcription factors comprises housekeeping regulators and their specialized paralogs, represented by well-studied NusG and RfaH. Despite their ubiquity, little information is available on the evolutionary origins, functions, and gene targets of the NusG family members. We built a hidden Markov model profile of RfaH and identified its homologs in sequenced genomes. While...
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