Article

General Transcription Factor from <i>E. coli</i> with a Distinct Mechanism of Action

2023-09-17

Abstract excerpt

Gene expression in E. coli is controlled by well-established mechanisms that activate or repress transcription. Here, we identify CedA as an unconventional transcription factor specifically associated with the RNA polymerase (RNAP) σ 70 holoenzyme. Structural and biochemical analysis of CedA bound to RNAP reveal that it bridges distant domains of β and σ 70 subunits to stabilize an open-promoter complex. Remark...

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Literature Corpus work: 16f5f9d1-a611-5c8e-b96c-46681fef80b9
DOI: 10.1101/2023.09.17.558134

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