Article
The conserved ribonuclease aCPSF1 triggers genome-wide transcription termination of Archaea via a 3'-end cleavage mode.
Nucleic acids research - 25 Sept 2020
Yue Lei, Li Jie, Zhang Bing, Qi Lei, Li Zhihua, Zhao Fangqing, Li Lingyan, Zheng Xiaowei, Dong Xiuzhu
Abstract excerpt
Transcription termination defines accurate transcript 3'-ends and ensures programmed transcriptomes, making it critical to life. However, transcription termination mechanisms remain largely unknown in Archaea. Here, we reported the physiological significance of the newly identified general transcription termination factor of Archaea, the ribonuclease aCPSF1, and elucidated its 3'-end cleavage triggered...
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