Article
Characterizing RNA Excited States Using NMR Relaxation Dispersion.
Methods in enzymology - 1 Jan 2015
Xue Yi, Kellogg Dawn, Kimsey Isaac J, Sathyamoorthy Bharathwaj, Stein Zachary W, McBrairty Mitchell, Al-Hashimi Hashim M
Abstract excerpt
Changes in RNA secondary structure play fundamental roles in the cellular functions of a growing number of noncoding RNAs. This chapter describes NMR-based approaches for characterizing microsecond-to-millisecond changes in RNA secondary structure that are directed toward short-lived and low-populated species often referred to as "excited states." Compared to larger scale changes in RNA secondary structure,...
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