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Association Between the COMT Val158Met Polymorphism and Antipsychotic Efficacy in Schizophrenia: An Updated Meta-Analysis.

Current neuropharmacology - 1 Jan 2021

Ma Jingsong, Zhao Mingzhe, Zhou Wei, Li Mo, Huai Cong, Shen Lu, Wang Ting, Wu Hao, Zhang Na, Zhang Zhiruo, He Lin, Qin Shengying

Abstract excerpt

BACKGROUND: Catechol-O-methyltransferase (COMT) contributes to the control of synaptic dopamine (DA) transmission by catalyzing DA degradation in the presynaptic space. The COMT Val158Met polymorphism (rs4680) substantially alters enzymatic activity and consequently synaptic DA concentration in the prefrontal cortex and hippocampus. The COMT genotype could, therefore, exert a major influence on antipsychotic...

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Antipsychotic Agents
Catechol O-Methyltransferase
Genetic Associations and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Neurotransmitter Receptor Influence on Behavior

Polymorphism, Single Nucleotide

Schizophrenia research and treatment

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Open in PubMed Open full text

Identifiers

PMID: 33100205
DOI: 10.2174/1570159X18666201023154049
PMCID: PMC8977635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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