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Article

Genetic Variations in the Dopaminergic Signaling Pathways and Their Implications for Antipsychotics Pharmacogenetics.

Journal of molecular neuroscience : MN - 27 Mar 2026

Olasore Holiness S A, Olawale Matthew O, Asiwaju Damilare P, Olashore Anthony A

Abstract excerpt

The role of neurotransmitter systems in the pathology and management of psychiatric disorders is well documented. Targeting these systems has remained the mainstay of standard pharmacological interventions, with typical and atypical antipsychotics demonstrating effectiveness in reducing both positive and negative symptoms of schizophrenia. However, their clinical efficacy and side effect profiles vary among...

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Share to Antipsychotic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41888498
DOI: 10.1007/s12031-026-02505-0

Genes

COMT

Variants

rs4680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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