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COMT Val158Met and 5-HT1A-R -1019 C/G polymorphisms: effects on the negative symptom response to clozapine.

Pharmacogenomics - 1 Jan 2015

Bosia Marta, Lorenzi Cristina, Pirovano Adele, Guglielmino Carmelo, Cocchi Federica, Spangaro Marco, Bramanti Placido, Smeraldi Enrico, Cavallaro Roberto

Abstract excerpt

AIM: Clozapine is still considered the gold standard for treatment-resistant schizophrenia patients; however, up to 40% of patients do not respond adequately. Identifying potential predictors of clinical response to this last-line antipsychotic could represent an important goal for treatment. Among these, functional polymorphisms involved in dopamine system modulation, known to be disrupted in schizophrenia, may...

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Biomarkers, Pharmacological
Catechol O-Methyltransferase
Clozapine
Dopamine
Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Receptor, Serotonin, 5-HT1A

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Identifiers

PMID: 25560469
DOI: 10.2217/pgs.14.150

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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