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Article

Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia.

Scientific reports - 22 Jun 2020

Nikolac Perkovic Matea, Sagud Marina, Zivkovic Maja, Uzun Suzana, Nedic Erjavec Gordana, Kozumplik Oliver, Svob Strac Dubravka, Mimica Ninoslav, Mihaljevic Peles Alma, Pivac Nela

Abstract excerpt

Antipsychotic drugs target primarily dopaminergic system which makes catechol-O-methyltransferase (COMT) an interesting target in studies searching for treatment response predictors in schizophrenia. The study assessed the association of the COMT rs4680 and rs4818 polymorphisms with therapeutic response to olanzapine, risperidone, clozapine or other antipsychotic medication after 8 weeks of monotherapy in...

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Identifiers

PMID: 32572118
DOI: 10.1038/s41598-020-67351-5
PMCID: PMC7308339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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