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Article

Blocking Mitochondrial Pyruvate Transport Alters Corneal Myofibroblast Phenotype: A New Target for Treating Fibrosis.

Investigative ophthalmology & visual science - 3 Oct 2023

Jeon Kye-Im, Kumar Ankita, Callan Christine L, DeMagistris Margaret, MacRae Scott, Nehrke Keith, Huxlin Krystel R

Abstract excerpt

Purpose: The purpose of this study was to critically test the hypothesis that mitochondrial pyruvate carrier (MPC) function is essential for maintenance of the corneal myofibroblast phenotype in vitro and in vivo. Methods: Protein and mRNA for canonical profibrotic markers were assessed in cultured cat corneal myofibroblasts generated via transforming growth factor (TGF)-β1 stimulation and treated with either the...

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Identifiers

PMID: 37870848
DOI: 10.1167/iovs.64.13.36
PMCID: PMC10599161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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