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Article

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.

Free radical biology & medicine - 1 Nov 2014

Ozden Ozkan, Park Seong-Hoon, Wagner Brett A, Song Ha Yong, Zhu Yueming, Vassilopoulos Athanassios, Jung Barbara, Buettner Garry R, Gius David

Abstract excerpt

Pyruvate dehydrogenase E1α (PDHA1) is the first component enzyme of the pyruvate dehydrogenase (PDH) complex that transforms pyruvate, via pyruvate decarboxylation, into acetyl-CoA that is subsequently used by both the citric acid cycle and oxidative phosphorylation to generate ATP. As such, PDH links glycolysis and oxidative phosphorylation in normal as well as cancer cells. Herein we report that SIRT3 interacts...

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Source

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Identifiers

PMID: 25152236
DOI: 10.1016/j.freeradbiomed.2014.08.001
PMCID: PMC4364304

Genes

PDHA1
SIRT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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