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Article

Neuronal degeneration and cognitive impairment can be prevented via the normalization of mitochondrial dynamics.

Pharmacological research - 1 Jan 2021

Ishikawa Kaori, Yamamoto Satoshi, Hattori Satoko, Nishimura Naoya, Matsumoto Hirokazu, Miyakawa Tsuyoshi, Nakada Kazuto

Abstract excerpt

Neuronal cells possess a certain degree of plasticity to recover from cell damage. When the stress levels are higher than their plasticity capabilities, neuronal degeneration is triggered. However, the factors correlated to the plasticity capabilities need to be investigated. In this study, we generated a novel mouse model that able to express in an inducible manner a dominant-negative form of MFN2, a...

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Identifiers

PMID: 33086082
DOI: 10.1016/j.phrs.2020.105246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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