Article
Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death.
The EMBO journal - 16 Oct 2014
Martorell-Riera Alejandro, Segarra-Mondejar Marc, Muñoz Juan P, Ginet Vanessa, Olloquequi Jordi, Pérez-Clausell Jeús, Palacín Manuel, Reina Manuel, Puyal Julien, Zorzano Antonio, Soriano Francesc X
Abstract excerpt
Mitochondrial fusion and fission is a dynamic process critical for the maintenance of mitochondrial function and cell viability. During excitotoxicity neuronal mitochondria are fragmented, but the mechanism underlying this process is poorly understood. Here, we show that Mfn2 is the only member of the mitochondrial fusion/fission machinery whose expression is reduced in in vitro and in vivo models of...
Topics
- Animals
- Calcium
- Cell Death
- Cell Line
- Cells, Cultured
- Down-Regulation
- Dynamins
- GTP Phosphohydrolases
- Gene Expression Regulation
- Homeostasis