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Article

Mitochondrial hyperfusion causes neuropathy in a fly model of CMT2A.

EMBO reports - 1 Aug 2018

Ueda Eri, Ishihara Naotada

Abstract excerpt

Mitochondria undergo frequent fusion and fission events, which are essential to maintain a functional mitochondrial network. A disruption of these processes can cause severe neurodegeneration. Charcot-Marie-Tooth disease type 2A (CMT2A) is a neuropathy that is caused by mutations in the fusion factor Mfn2. It is generally assumed that impaired mitochondrial fusion causes CMT2A. However, the detailed molecular...

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Identifiers

PMID: 30030216
DOI: 10.15252/embr.201846502
PMCID: PMC6073202

Genes

MFN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mitochondrial hyperfusion causes neuropathy in a fly model of CMT2A.PMID 30030216Read ↗

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