Article
ER stress-induced modulation of neural activity and seizure susceptibility is impaired in a fragile X syndrome mouse model.
Neurobiology of disease - 1 Oct 2021
Liu Dai-Chi, Lee Kwan Young, Lizarazo Simon, Cook Jessie K, Tsai Nien-Pei
Abstract excerpt
Imbalanced neuronal excitability homeostasis is commonly observed in patients with fragile X syndrome (FXS) and the animal model of FXS, the Fmr1 KO. While alterations of neuronal intrinsic excitability and synaptic activity at the steady state in FXS have been suggested to contribute to such a deficit and ultimately the increased susceptibility to seizures in FXS, it remains largely unclear whether and how the...
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