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A Jacob/nsmf gene knockout does not protect against hypoxia- and NMDA-induced neuronal cell death

2022-12-21

Abstract excerpt

<h4>ABSTRACT</h4> Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case of synaptic or extrasynaptic NMDAR activation. Following nuclear import Jacob docks these signalosomes to the transcription factor CREB. We have recently shown that amyloid-beta and extrasy...

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Literature Corpus work
47a1a82c-5af7-55a7-8298-74124cf67050
DOI
10.1101/2022.12.20.521175
Open publication

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A Jacob/nsmf gene knockout does not protect against hypoxia- and NMDA-induced neuronal cell deathDOI 10.1101/2022.12.20.521175
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