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Chronic mild stress disrupts mitophagy and mitochondrial status in rat frontal cortex

23 May 2025

Abstract excerpt

BACKGROUND: Mitochondria are very dynamic organelles that maintain cellular homeostasis, crucial in the central nervous system. Mitochondrial abnormalities have been described in neuropsychiatric diseases, namely major depression disorder (MDD) and schizophrenia. Since stress is the predominant non-genetic cause of MDD, and has a direct impact on mitochondrial networks, understanding how psychological stress...

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PMID: 40410878
DOI: 10.1186/s12967-025-06604-1

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