Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex

1 Feb 2018

Abstract excerpt

BACKGROUND: Mitochondria are the organelles responsible for energy metabolism and have a direct impact on neuronal function and survival. Mitochondrial abnormalities have been well characterized in Alzheimer Disease (AD). It is believed that mitochondrial fragmentation, due to impaired fission and fusion balance, likely causes mitochondrial dysfunction that underlies many aspects of neurodegenerative changes in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Amyotrophic Lateral Sclerosis Research
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29391029
DOI: 10.1186/s13024-018-0238-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortexPMID 29391029Read ↗

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease.Semantic proximity Read ↗

Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell.Semantic proximity Read ↗

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s diseaseSemantic proximity Read ↗

A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer's DiseaseSemantic proximity Read ↗

Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death.Semantic proximity Read ↗

Alterations in Mitochondrial Quality Control in Alzheimer’s DiseaseSemantic proximity Read ↗

Dysregulation of mitochondrial fusion and fission: an emerging concept in neurodegeneration.Semantic proximity Read ↗

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease.Semantic proximity Read ↗

Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 MiceSemantic proximity Read ↗

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and DiseaseSemantic proximity Read ↗

Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagySemantic proximity Read ↗

Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.