Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit.

Human molecular genetics - 15 Nov 2012

Pham Anh H, Meng Shuxia, Chu Quynh N, Chan David C

Abstract excerpt

Mitochondria continually undergo fusion and fission, and these dynamic processes play a major role in regulating mitochondrial function. Studies of several genes associated with familial Parkinson's disease (PD) have implicated aberrant mitochondrial dynamics in the disease pathology, but the importance of these processes in dopaminergic neurons remains poorly understood. Because the mitofusins Mfn1 and Mfn2 are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Corpus Striatum
Share to Dopaminergic Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to Levodopa

Share to Mitochondria

Share to Motor Activity

Share to Movement Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 22859504
DOI: 10.1093/hmg/dds311
PMCID: PMC3607482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit.PMID 22859504Read ↗

Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons.Semantic proximity Read ↗

Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations.Semantic proximity Read ↗

Vulnerable Parkin Loss-of-Function Drosophila Dopaminergic Neurons Have Advanced Mitochondrial Aging, Mitochondrial Network Loss and Transiently Reduced Autophagosome RecruitmentSemantic proximity Read ↗

Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex.Semantic proximity Read ↗

Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortexSemantic proximity Read ↗

Mitochondrial hyperfusion causes neuropathy in a fly model of CMT2A.Semantic proximity Read ↗

Imbalanced mitochondrial dynamics in human and mouse PD brainsSemantic proximity Read ↗

CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd miceSemantic proximity Read ↗

Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.Semantic proximity Read ↗

Selective mitochondrial depletion, apoptosis resistance, and increased mitophagy in human Charcot-Marie-Tooth 2A motor neuronsSemantic proximity Read ↗

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neuronsSemantic proximity Read ↗

Mitofusin 2 Dysfunction and Disease in Mice and MenSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.