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Article

Energy sensing and cancer: LKB1 function and lessons learnt from Peutz-Jeghers syndrome.

Seminars in cell & developmental biology - 1 Apr 2016

Shorning Boris Y, Clarke Alan R

Abstract excerpt

We describe in this review increasing evidence that loss of LKB1 kinase in Peutz-Jeghers syndrome (PJS) derails the existing natural balance between cell survival and tumour growth suppression. LKB1 deletion can plunge cells into an energy/oxidative stress-induced crisis which leads to the activation of alternative and often carcinogenic pathways to maintain cellular energy levels. It therefore appears that...

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Identifiers

PMID: 26877140
DOI: 10.1016/j.semcdb.2016.02.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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