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Article

Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction.

eLife - 16 Oct 2020

Alonso-Herranz Laura, Sahún-Español Álvaro, Paredes Ana, Gonzalo Pilar, Gkontra Polyxeni, Núñez Vanessa, Clemente Cristina, Cedenilla Marta, Villalba-Orero María, Inserte Javier, García-Dorado David, Arroyo Alicia G, Ricote Mercedes

Abstract excerpt

Macrophages (Mφs) produce factors that participate in cardiac repair and remodeling after myocardial infarction (MI); however, how these factors crosstalk with other cell types mediating repair is not fully understood. Here we demonstrated that cardiac Mφs increased the expression of Mmp14 (MT1-MMP) 7 days post-MI. We selectively inactivated the Mmp14 gene in Mφs using a genetic strategy (Mmp14f/f:Lyz2-Cre). This...

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Identifiers

PMID: 33063665
DOI: 10.7554/eLife.57920
PMCID: PMC7609061

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