Article
Chemokine-like receptor 1 deficiency impedes macrophage phenotypic transformation and cardiac repair after myocardial infarction.
International journal of cardiology - 1 Feb 2023
Wang Caiping, Zhang Min, Yan Jianlong, Wang Rongning, Wang Zhefeng, Sun Xin, Dong Shaohong
Abstract excerpt
BACKGROUND: Timely and appropriate transformation of macrophage phenotypes from proinflammatory to anti-inflammatory is essential for cardiac repair after myocardial infarction (MI). Chemokine-like receptor 1 (CMKLR1), which is expressed on macrophages, is regulated by proinflammatory and anti-inflammatory stimuli. However, the contribution of CMKLR1 to macrophage phenotypic transformation and the role it plays...
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