Article
Cortical bone stem cells modify cardiac inflammation after myocardial infarction by inducing a novel macrophage phenotype.
American journal of physiology. Heart and circulatory physiology - 1 Oct 2021
Hobby Alexander R H, Berretta Remus M, Eaton Deborah M, Kubo Hajime, Feldsott Eric, Yang Yijun, Headrick Alaina L, Koch Keith A, Rubino Marcello, Kurian Justin, Khan Mohsin, Tan Yinfei, Mohsin Sadia, Gallucci Stefania, McKinsey Timothy A, Houser Steven R
Abstract excerpt
Acute damage to the heart, as in the case of myocardial infarction (MI), triggers a robust inflammatory response to the sterile injury that is part of a complex and highly organized wound-healing process. Cortical bone stem cell (CBSC) therapy after MI has been shown to reduce adverse structural and functional remodeling of the heart after MI in both mouse and swine models. The basis for these CBSC treatment...
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