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Article

Macrophages in the infarcted heart acquire a fibrogenic phenotype, expressing matricellular proteins, but do not undergo fibroblast conversion.

Journal of molecular and cellular cardiology - 1 Nov 2024

Li Ruoshui, Hanna Anis, Huang Shuaibo, Hernandez Silvia C, Tuleta Izabela, Kubota Akihiko, Humeres Claudio, Chen Bijun, Liu Yang, Zheng Deyou, Frangogiannis Nikolaos G

Abstract excerpt

Although some studies have suggested that macrophages may secrete structural collagens, and convert to fibroblast-like cells, macrophage to fibroblast transdifferentiation in infarcted and remodeling hearts remains controversial. Our study uses linage tracing approaches and single cell transcriptomics to examine whether macrophages undergo fibroblast conversion, and to characterize the extracellular matrix...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39089570
DOI: 10.1016/j.yjmcc.2024.07.010
PMCID: PMC11534516

Genes

CSF1R
CX3CR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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