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Article

The role of endogenous Smad7 in regulating macrophage phenotype following myocardial infarction.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2022

Li Jun, Li Ruoshui, Tuleta Izabela, Hernandez Silvia C, Humeres Claudio, Hanna Anis, Chen Bijun, Frangogiannis Nikolaos G

Abstract excerpt

Smad7 restrains TGF-β responses, and has been suggested to exert both pro- and anti-inflammatory actions that may involve effects on macrophages. Myocardial infarction triggers a macrophage-driven inflammatory response that not only plays a central role in cardiac repair, but also contributes to adverse remodeling and fibrosis. We hypothesized that macrophage Smad7 expression may regulate inflammation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35695814
DOI: 10.1096/fj.202101956RR
PMCID: PMC9216182

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