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Article

Macrophage overexpression of matrix metalloproteinase-9 in aged mice improves diastolic physiology and cardiac wound healing after myocardial infarction.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2018

Meschiari Cesar A, Jung Mira, Iyer Rugmani Padmanabhan, Yabluchanskiy Andriy, Toba Hiroe, Garrett Michael R, Lindsey Merry L

Abstract excerpt

Matrix metalloproteinase (MMP)-9 increases in the myocardium with advanced age and after myocardial infarction (MI). Because young transgenic (TG) mice overexpressing human MMP-9 only in macrophages show better outcomes post-MI, whereas aged TG mice show a worse aging phenotype, we wanted to evaluate the effect of aging superimposed on MI to see if the detrimental effect of aging counteracted the benefits of...

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Identifiers

PMID: 29030341
DOI: 10.1152/ajpheart.00453.2017
PMCID: PMC5867652

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