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Article

YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction.

PLoS biology - 1 Dec 2020

Mia Masum M, Cibi Dasan Mary, Abdul Ghani Siti Aishah Binte, Song Weihua, Tee Nicole, Ghosh Sujoy, Mao Junhao, Olson Eric N, Singh Manvendra K

Abstract excerpt

Adverse cardiac remodeling after myocardial infarction (MI) causes structural and functional changes in the heart leading to heart failure. The initial post-MI pro-inflammatory response followed by reparative or anti-inflammatory response is essential for minimizing the myocardial damage, healing, and scar formation. Bone marrow-derived macrophages (BMDMs) are recruited to the injured myocardium and are essential...

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Share to Adaptor Proteins, Signal Transducing
Share to Biological Variation, Population

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33264286
DOI: 10.1371/journal.pbio.3000941
PMCID: PMC7735680

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