Article

Macrophages and fibroblasts in cardiac fibrosis: interactions and transformation

2025-08-18

Abstract excerpt

Cardiac fibrosis, characterized by excessive extracellular matrix (ECM) deposition, plays a central role in the progression of heart diseases such as myocardial infarction, heart failure, and hypertensive cardiomyopathy. The dynamic interplay between fibroblasts and macrophages is pivotal in regulating ECM remodeling and the fibrotic response. Fibroblasts, as primary ECM producers, undergo phenotypic changes durin...

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Literature Corpus work: ec8d38d7-1936-5111-907b-1ef4b8fccf41
DOI: 10.37349/ei.2025.1003211

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