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Article

The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity.

Scientific reports - 15 Oct 2020

Gorchs Laia, Ahmed Sultan, Mayer Chanté, Knauf Alisa, Fernández Moro Carlos, Svensson Mattias, Heuchel Rainer, Rangelova Elena, Bergman Peter, Kaipe Helen

Abstract excerpt

The pancreatic tumour stroma is composed of phenotypically heterogenous cancer-associated fibroblasts (CAFs) with both pro- and anti-tumorigenic functions. Here, we studied the impact of calcipotriol, a vitamin D3 analogue, on the activation of human pancreatic CAFs and T cells using 2- and 3-dimensional (2D, 3D) cell culture models. We found that calcipotriol decreased CAF proliferation and migration and reduced...

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Identifiers

PMID: 33060625
DOI: 10.1038/s41598-020-74368-3
PMCID: PMC7562723

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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