Article

The pancreatic cancer secretome alters cells in the tumor microenvironment through the STAT3 pathway to induce a muscle atrophic phenotype

2026-04-23

Abstract excerpt

<title>Abstract</title> <p>The pancreatic tumor microenvironment, a major component of pancreatic tumors, plays important roles in tumor progression, metastasis, and chemotherapy resistance. In patients with advanced pancreatic cancer, unintentional weight loss by muscle and/or adipose tissue atrophy, called cancer cachexia, is frequently observed. Although it is well established that cancer cells secrete muscle...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 566c1b7d-0337-5155-97fb-7f31eaf2557c
DOI: 10.21203/rs.3.rs-9296107/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

The pancreatic cancer secretome alters cells in the tumor microenvironment through the STAT3 pathway to induce a muscle atrophic phenotypeDOI 10.21203/rs.3.rs-9296107/v1Read

The Cellular Origins of Cancer-Associated Fibroblasts and Their Opposing Contributions to Pancreatic Cancer GrowthSemantic proximity Read

Cancer‐associated fibroblasts that restrain cancer progression: Hypotheses and perspectivesSemantic proximity Read

Biology of pancreatic stellate cells—more than just pancreatic cancerSemantic proximity Read

The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinomaSemantic proximity Read

Pancreatic cancer stroma: controversies and current insightsSemantic proximity Read

Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor.Semantic proximity Read

Characterization of tumor-derived pancreatic stellate cells.Semantic proximity Read

High throughput screen in a co-culture model to uncover therapeutic strategies to potentiate the cancer-inhibiting properties of the tumor-stroma in pancreatic cancerSemantic proximity Read

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumorsSemantic proximity Read

Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer CellsSemantic proximity Read

Single Cell Analysis of Cultivated Fibroblasts from Chronic Pancreatitis and Pancreatic Cancer PatientsSemantic proximity Read

Activated Human Pancreatic Stellate Cells Signature Communication in Type 1 DiabetesSemantic proximity Read