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Article

Galectin-3 Mediates Tumor Cell-Stroma Interactions by Activating Pancreatic Stellate Cells to Produce Cytokines via Integrin Signaling.

Gastroenterology - 1 Apr 2018

Zhao Wei, Ajani Jaffer A, Sushovan Guha, Ochi Nobuo, Hwang Rosa, Hafley Margarete, Johnson Randy L, Bresalier Robert S, Logsdon Craig D, Zhang Zhiqian, Song Shumei

Abstract excerpt

BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) is characterized by activated pancreatic stellate cells (PSCs), abundance of extracellular matrix (ECM), and production of cytokines and chemokines. Galectin 3 (GAL3), a β-galactoside-specific lectin, contributes to PDAC development but its effects on the stroma and cytokine production are unclear. METHODS: The effect of recombinant human GAL3 (rGAL3) on...

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Source

Identifiers

PMID: 29274868
DOI: 10.1053/j.gastro.2017.12.014

Genes

ILK
ITGB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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