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Vitamin D Effects on Cell Differentiation and Stemness in Cancer

25 Aug 2020

Abstract excerpt

Vitamin D3 is the precursor of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), a pleiotropic hormone that is a major regulator of the human genome. 1,25(OH)2D3 modulates the phenotype and physiology of many cell types by controlling the expression of hundreds of genes in a tissue- and cell-specific fashion. Vitamin D deficiency is common among cancer patients and numerous studies have reported that 1,25(OH)2D3 promotes...

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PMID: 32854355
DOI: 10.3390/cancers12092413

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