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Natural Killer Cell-Based Therapy Combined with Probiotic Bacteria Supplementation Plays a Crucial Role in Regulating Bone Restoration in Cancer, Highlighting the Significance of IFN-γ

2025-07-30

Abstract excerpt

This study uncovered a significant correlation between interferon-gamma (IFN-γ) secretion from immune cells and bone quality alterations in pancreatic cancer-bearing humanized-BLT (hu-BLT) mice. Reduced bone formation and IFN‐γ inhibition were observed in tumor mice versus those without tumors. When AJ2 probiotic bacteria were fed to MP2 pancreatic tumor-bearing mice, it increased bone integrity compared to tumor-...

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Literature Corpus work
06cddbd9-3552-5a4e-a8a6-b6e02e16d64e
DOI
10.20944/preprints202507.2488.v1
Open publication

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Natural Killer Cell-Based Therapy Combined with Probiotic Bacteria Supplementation Plays a Crucial Role in Regulating Bone Restoration in Cancer, Highlighting the Significance of IFN-γDOI 10.20944/preprints202507.2488.v1
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