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Article

Cooperative induction of a tolerogenic dendritic cell phenotype by cytokines secreted by pancreatic carcinoma cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2006

Bellone Graziella, Carbone Anna, Smirne Carlo, Scirelli Tiziana, Buffolino Alessandra, Novarino Anna, Stacchini Alessandra, Bertetto Oscar, Palestro Giorgio, Sorio Claudio, Scarpa Aldo, Emanuelli Giorgio, Rodeck Ulrich

Abstract excerpt

Ag presentation by dendritic cells (DC) is essential to effective antitumor T cell responses in cancer patients. Depending on their origin, maturation state, and the ambient cytokine milieu, DC can differentiate into distinct subpopulations, which preferentially either induce Th1 cell activation (CD11c+,CD123- myeloid DC (MDC)) or immunosuppressive T cell development (CD11c-,CD123+ plasmacytoid DC (PDC)). The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16920987
DOI: 10.4049/jimmunol.177.5.3448

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PDC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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