Article

High throughput screen in a co-culture model to uncover therapeutic strategies to potentiate the cancer-inhibiting properties of the tumor-stroma in pancreatic cancer

2022-03-13

Abstract excerpt

P ancreatic stellate c ells (PSCs) differentiate into multiple subtypes of c ancer a ssociated fibroblasts (CAFs) that modulate disease progression in p ancreatic d uctal a deno c arcinoma (PDAC). CAF subtypes demonstrate functional heterogeneity in tumor development, with conflicting consequences for disease progression. Here, we show that my ofibroblastic CAFs (myCAFs), but not inflammatory CAFs (iCAFs),...

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Literature Corpus work: f879b607-7167-593b-b33e-6d36954c1484
DOI: 10.1101/2022.03.11.483991

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High throughput screen in a co-culture model to uncover therapeutic strategies to potentiate the cancer-inhibiting properties of the tumor-stroma in pancreatic cancerDOI 10.1101/2022.03.11.483991Read

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