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Determination of low-abundance single-base point mutations based on endonuclease IV and branch migration system.

Analytica chimica acta - 16 Oct 2020

Tang Xiaofeng, Chen Na, Liu Ruijie, Hu Qingyi, Liu Na, Xiao Xianjin

Abstract excerpt

Combining endonuclease IV and branch migration competition systems, we have designed a new single-base mutation detection method which is capable of thermostatic, sensitive, simple, and cost-effective at the same time, while other probe method based on endonuclease IV hardly achieve. Our method has better discrimination factors (6.81-83.10) and a low abundance detection limit of mutant-type DNA (MT) (0.05%...

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PMID: 33059863
DOI: 10.1016/j.aca.2020.08.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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