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Article

Phosphoramidate Azole Oligonucleotides for Single Nucleotide Polymorphism Detection by PCR.

International journal of molecular sciences - 3 Jan 2024

Chubarov Alexey S, Baranovskaya Elizaveta E, Oscorbin Igor P, Yushin Ivan I, Filipenko Maxim L, Pyshnyi Dmitrii V, Vasilyeva Svetlana V, Lomzov Alexander A

Abstract excerpt

Detection of the Kirsten rat sarcoma gene (KRAS) mutational status is an important factor for the treatment of various malignancies. The most common KRAS-activating mutations are caused by single-nucleotide mutations, which are usually determined by using PCR, using allele-specific DNA primers. Oligonucleotide primers with uncharged or partially charged internucleotide phosphate modification have proved their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38203788
DOI: 10.3390/ijms25010617
PMCID: PMC10778797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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