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Article

A tailored LNA clamping design principle: Efficient, economized, specific and ultrasensitive for the detection of point mutations.

Biotechnology journal - 1 Oct 2021

Yang Hao, Yan Mengqiu, Xu Gaolian, Qian Xiaohua, Zhao Ruiying, Han Yuchen, Zhang Lin, Gu Hongchen, Xu Hong

Abstract excerpt

In the development of personalized medicine, the ultrasensitive detection of point mutations that correlate with diseases is important to improve the efficacy of treatment and guide clinical medication. In this study, locked nucleic acid (LNA) was introduced as an amplification suppressor of a massive number of wild-type alleles in an amplification refractory mutation system (ARMS) to achieve the detection of...

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PMID: 34278717
DOI: 10.1002/biot.202100233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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