Article

A tailored LNA clamping design principle: efficient, economized, specific and ultrasensitive for the detection of point mutations

2021-05-17

Abstract excerpt

In the development of personalized medicine, the ultrasensitive detection of point mutations that correlate with diseases is important to improve the efficacy of treatment and guide clinical medication. In this study, locked nucleic acid (LNA) was introduced as an amplification suppressor of a massive number of wild-type alleles in an amplification refractory mutation system (ARMS) to achieve the detection of low-...

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Literature Corpus work: 5e05db7b-2901-523d-8b88-c5c9147215af
DOI: 10.22541/au.162128311.16782690/v1

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