Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA helicases, genomic instability, and human genetic disease.

Annual review of genomics and human genetics - 1 Jan 2000

van Brabant A J, Stan R, Ellis N A

Abstract excerpt

DNA helicases are a highly conserved group of enzymes that unwind DNA. They function in all processes in which access to single-stranded DNA is required, including DNA replication, DNA repair and recombination, and transcription of RNA. Defects in helicases functioning in one or more of these processes can result in characteristic human genetic disorders in which genomic instability and predisposition to cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bloom Syndrome
Share to DNA Helicases
Share to Rothmund-Thomson Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to TATA-Binding Protein Associated Factors

Share to Transcription Factor TFIID

Share to Transcription Factor TFIIH

Share to Transcription Factors, TFII

Share to Werner Syndrome

Source

Identifiers

PMID: 11701636
DOI: 10.1146/annurev.genom.1.1.409

Genes

BLM
RECQL4
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA helicases, genomic instability, and human genetic disease.PMID 11701636Read ↗

DNA helicases associated with genetic instability, cancer, and aging.Semantic proximity Read ↗

Human RecQ Helicases in DNA Double-Strand Break RepairSemantic proximity Read ↗

An overview of RecQ helicases and related diseases.Semantic proximity Read ↗

RecQ family helicases in genome stability: lessons from gene disruption studies in DT40 cells.Semantic proximity Read ↗

DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.Semantic proximity Read ↗

DNA repair helicases: from mechanistic understanding to therapeutic implications.Semantic proximity Read ↗

Premature aging and predisposition to cancers caused by mutations in RecQ family helicases.Semantic proximity Read ↗

Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology.Semantic proximity Read ↗

Human premature aging, DNA repair and RecQ helicases.Semantic proximity Read ↗

Molecular genetics of RecQ helicase disorders.Semantic proximity Read ↗

RecQ helicases: suppressors of tumorigenesis and premature aging.Semantic proximity Read ↗

Unique and important consequences of RECQ1 deficiency in mammalian cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.