Article
Human premature aging, DNA repair and RecQ helicases.
Nucleic acids research - 1 Jan 2007
Brosh Robert M, Bohr Vilhelm A
Abstract excerpt
Genomic instability leads to mutations, cellular dysfunction and aberrant phenotypes at the tissue and organism levels. A number of mechanisms have evolved to cope with endogenous or exogenous stress to prevent chromosomal instability and maintain cellular homeostasis. DNA helicases play important roles in the DNA damage response. The RecQ family of DNA helicases is of particular interest since several human RecQ...
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