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Article

RecQ family helicases: roles in cancer and aging.

Current opinion in genetics & development - 1 Feb 2000

Karow J K, Wu L, Hickson I D

Abstract excerpt

The RecQ family of DNA helicases includes at least three members in humans that are defective in genetic disorders associated with cancer predisposition and/or premature aging. Recent studies have shed light on the roles of RecQ helicases in suppressing 'promiscuous' genetic recombination and in ensuring accurate chromosome segregation. In particular, the biochemical properties of several family members have been...

Read the complete abstract on PubMed

Topics

Adenosine Triphosphatases
Aging
Animals
DNA Helicases
DNA Replication
Escherichia coli
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Neoplasms

RecQ Helicases

Recombination, Genetic

Yeasts

Source

Identifiers

PMID: 10679384
DOI: 10.1016/s0959-437x(99)00039-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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