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Article

Adaptive immunity selects against malaria infection blocking mutations.

PLoS computational biology - 1 Oct 2020

Penman Bridget S, Gandon Sylvain

Abstract excerpt

The mutation responsible for Duffy negativity, which impedes Plasmodium vivax infection, has reached high frequencies in certain human populations. Conversely, mutations capable of blocking the more lethal P. falciparum have not succeeded in malarious zones. Here we present an evolutionary-epidemiological model of malaria which demonstrates that if adaptive immunity against the most virulent effects of malaria is...

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Identifiers

PMID: 33031369
DOI: 10.1371/journal.pcbi.1008181
PMCID: PMC7544067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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