Article
Adaptive immunity selects against malaria infection blocking mutations.
PLoS computational biology - 1 Oct 2020
Penman Bridget S, Gandon Sylvain
Abstract excerpt
The mutation responsible for Duffy negativity, which impedes Plasmodium vivax infection, has reached high frequencies in certain human populations. Conversely, mutations capable of blocking the more lethal P. falciparum have not succeeded in malarious zones. Here we present an evolutionary-epidem...
Topics
- Adaptive Immunity
- Computational Biology
- Evolution, Molecular
- Genetic Predisposition to Disease
- Humans
- Malaria, Falciparum
- Malaria, Vivax
- Models, Genetic
- Mutation
- Plasmodium falciparum
- Plasmodium vivax