Genomic Analysis of Plasmodium vivax in Southern Ethiopia Reveals Selective Pressures in Multiple Parasite Mechanisms.

doi:10.1093/infdis/jiz016

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Article

Genomic Analysis of Plasmodium vivax in Southern Ethiopia Reveals Selective Pressures in Multiple Parasite Mechanisms.

The Journal of infectious diseases - 22 Oct 2019

Auburn Sarah, Getachew Sisay, Pearson Richard D, Amato Roberto, Miotto Olivo, Trimarsanto Hidayat, Zhu Sha Joe, Rumaseb Angela, Marfurt Jutta, Noviyanti Rintis, Grigg Matthew J, Barber Bridget, William Timothy, Goncalves Sonia Morgado, Drury Eleanor, Sriprawat Kanlaya, Anstey Nicholas M, Nosten Francois, Petros Beyene, Aseffa Abraham, McVean Gil, Kwiatkowski Dominic P, Price Ric N

Abstract excerpt

The Horn of Africa harbors the largest reservoir of Plasmodium vivax in the continent. Most of sub-Saharan Africa has remained relatively vivax-free due to a high prevalence of the human Duffy-negative trait, but the emergence of strains able to invade Duffy-negative reticulocytes poses a major public health threat. We undertook the first population genomic investigation of P. vivax from the region, comparing the...

Topics

Adaptation, Biological
Adolescent
Animals
Child
Child, Preschool
Ethiopia
Female
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant

Infant, Newborn

Malaria, Vivax

Male

Plasmodium vivax

Prevalence

Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 30668735
DOI: 10.1093/infdis/jiz016
PMCID: PMC6804337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-30668735-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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