Article

Deep learning analyses of DNA sequences resolve the retention of the Duffy-null resistance to Plasmodium vivax malaria in Africa

2025-12-26

Abstract excerpt

P. vivax , the most geographically widespread human malaria parasite with millions of clinical cases per year, is however quasi absent in sub-Saharan Africa. Positive selection targeting the rs2814778 protective mutation, also known as the Duffy-null allele, may explain the absence (or quasi absence) of vivax in sub-Saharan Africa by a progressive purge of the pathogen due to a quasi-fixation of the Duffy-null al...

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Literature Corpus work: bc1a421c-c4ae-5df0-8059-bfb18ffe700b
DOI: 10.64898/2025.12.25.695976

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